Use a high-gain "Marshall" style crunch. Not too much distortion; you want to hear the individual notes in the fast riffs.
Alternating between the open low E string (lowered to Eb) and melodic notes on the A and D strings. 06 Slash - Halo
The Slash - Apocalyptic Love songbook contains the professional "paper" sheet music with full notation and lyrics. Use a high-gain "Marshall" style crunch
Typically follows a climbing pattern (C5 - D5 - E5) to create a sense of anticipation. 06 Slash - Halo