Spray drying, milling, and spray-freeze drying are used to control the solid state and ensure stability.
Dispersibility, aerodynamic size (ideally 1–3 µm), and aerosolization stability. 🏗️ Manufacturing: High Flow & Density
5 µm) have high cohesion forces, causing agglomeration and poor flow. High Powder
Increased feed rates (up to 40.2 g/min) can stabilize particle trajectories.
Excessive flow rates may decrease deposition efficiency due to particle collisions. Spray drying, milling, and spray-freeze drying are used
Achieved by mixing different particle sizes (e.g., trimodal distributions) to fill voids.
High-dose powders are critical for treating lung infections or systemic diseases where large amounts of medication must reach the deep lungs. Delivered doses ≥is greater than or equal to Challenges: Fine particles (
In blasting operations, the refers to the amount of explosive (kg) needed to fracture a unit volume of rock.