A Day Makes — [s5e22] What A Difference

While the wedding takes center stage, the hospital remains in chaos due to a tragic car crash involving college students on their way to graduation.

: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts [S5E22] What a Difference a Day Makes

: After Derek and Bailey discover that Izzie has an inoperable brain tumor, the group decides to celebrate her life and love immediately. While the wedding takes center stage, the hospital

: Creator Shonda Rhimes noted that Denny's appearance in this episode was meant to represent "Death," which is why he wore black and spoke sparingly compared to previous appearances. While the wedding takes center stage