The most interesting aspect of variables in this system is their ; unlike older models that required dozens of inputs, EAGLE uses only six core features to predict interactions with high accuracy:

Based on the gene's FPKM score (from RNA-seq data), representing the transcriptional activity level in specific tissues.

Captures how multiple enhancers might work together to regulate a single gene. Contextual Meaning of the Name Based on the structure of the string:

The physical distance between the enhancer and the gene's transcription start site.