On September 15, 2022, Villarreal traveled to Israel for a demanding midweek fixture.

: Tomer Hemed put the visitors ahead in the 48th minute after a handball by Aïssa Mandi led to a penalty.

Villarreal ultimately dominated Group C, finishing first with 13 points, while Hapoel Be'er Sheva finished third, failing to advance to the knockout stages. These matches are remembered as a resilient effort by the Israeli side against a seasoned Spanish powerhouse that had recently won the Europa League.